Heart attack, stroke, blindness, amputation, kidney failure. When doctors
describe these diabetes complications, it may sound melodramatic -- like an
overblown worst-case scenario. The truth is, these things can happen when blood
sugar, blood pressure, and cholesterol are out of control.
"A lot of people don't really think it will happen to them," says David C.
Ziemer, MD, director of the Diabetes Clinic at Grady Hospital in Atlanta. "For
a lot of folks, the wake-up comes when they actually have a complication ... a
bad infection in the foot. That's a nasty wake-up call."
When insulin was first discovered in 1921, it's not an overstatement to say that it revolutionized the treatment of diabetes. No longer was diabetes considered a death sentence. For the first time, people with diabetes could expect to live longer, fuller lives.
Insulin transformed diabetes treatment, but for many decades it was the only drug available to treat diabetes. Then came another mini-revolution with the introduction of the first oral, non-insulin drugs to treat type 2 diabetes, including...
If you have uncontrolled diabetes, a serious and deep-seated foot infection
can mean loss of a toe, foot, or leg -- amputation -- to save your life.
How is this possible? Over time, high blood sugar slowly injures the blood
vessels, nerves, and organs in your body. The higher your blood sugar is -- and
the longer it stays high -- the worse the damage is. Smoking and alcohol
ratchet up the damage several more notches.
"Damage is slow and occurs over a period of years -- but it probably begins
when blood sugar is at mildly elevated levels," says Ronald Goldberg, MD,
associate director of the Diabetes Research Institute at the University of
Miami Medical Center. "You may not be diagnosed with diabetes, but the damage
has already begun."
The damage from diabetes shows up a bit differently in everyone -- whether
it attacks the nerves, eyes, or kidneys, Goldberg tells WebMD. "Genetics
probably influence which complications you are more susceptible to."
The problem is, "many people have diabetes a lot longer than they realize,"
says Ziemer. "Most have diabetes an average of five to seven years before
Diabetes Complications: The Risks You Face
As blood vessels, nerves, and organs become damaged, your risk of diabetes
complications increases. These are the most serious:
Heart disease, heart attack, heart failure, and stroke risks are doubled.
Heart disease and stroke cause at least 65% of deaths from diabetes.
Major eye complications (diabetic retinopathy) are linked to blood vessel
problems in the eyes. Diabetes is a leading cause of preventable blindness;
cataracts and glaucoma are also common.
Reduced blood flow to nerves and high blood sugar results in nerve pain,
burning, numbness (peripheral neuropathy).
Serious leg and foot infections, even gangrene and amputation, are due to
poor blood circulation, lack of oxygen and nutrients to tissue, and nerve
Kidney damage (diabetic nephropathy) is a common risk for people with
The complications of diabetes are indeed serious -- but they are not
inevitable, Ziemer tells WebMD. "Keeping blood sugar under control is the
single the most important factor in preventing them. But people have a hard
time grasping just how critical that is," he says. "It's hard to get them to
tune into it."