Live-Donor Transplant May Treat Diabetes
Woman Donates Half of Pancreas to Aid Daughter With Type 1 Diabetes
It won't be known for some time if live-donor islet cell transplants produce better long-term outcomes. And Shapiro acknowledges that questions remain about the safety of the procedure for the donor. One fear has been that if too much of the pancreas is removed the donor could also become diabetic.
Barrett says the experience from a French research team is reassuring. For several years the researchers have been doing a similar procedure, only instead of transplanting islet cells from the pancreas they have been transplanting a portion of the pancreas itself from live donors to diabetes patients.
"The donors are not entirely normal in terms of pancreatic function, but they seem to do pretty well," he says. "The fear that they would develop diabetes isn't being borne out."
Shapiro says there are plans to do more live-donor islet cell transplants in both Japan and at his institution in Edmonton.
"We are moving forward cautiously, but I am optimistic that this could supplement or even replace cadaveric transplants," he says. "There are clearly not enough organ donors to go around, and the living donor procedure could fulfill a clear niche. But, obviously, curing diabetes in one person at the expense of creating it in another would be an unacceptable and catastrophic outcome."