Wine Compound Spurs Diabetes Research
Scientists Make Chemicals That Act Like Red Wine's Resveratrol to Counter Diabetes in Mice
Nov. 29, 2007 -- Resveratrol, a compound found in wine and grapes, has
inspired scientists to create chemicals that may one day treat type 2
Red wine, grapes, raspberries, and peanuts are among the foods rich in
In October, Chinese researchers reported that
resveratrol curbs insulin resistance in mice. Insulin is a hormone that
controls blood sugar. Insulin resistance can lead to type 2 diabetes.
In today's edition of Nature, another team of scientists says it
has developed chemicals that behave like a souped-up version of
resveratrol in lab tests on diabetic mice.
Like resveratrol, the lab-made chemicals activate a gene called SIRT1,
making the diabetic mice more sensitive to insulin.
But the newly developed chemicals are 1,000 times more potent than
Those chemicals haven't yet been tested on people or in long-term
experiments, but they "hold promise" as a treatment for type 2
diabetes, write the researchers.
They included Christoph Westphal, MD, PhD. He's the CEO of Sirtris
Pharmaceuticals, which made the compounds tested in the study. Scientists from
Harvard Medical School and the University of California at San Diego also
worked on the study.