Sulfonylureas for Type 2 Diabetes
Examples
| Generic Name | Brand Name |
|---|---|
| glimepiride | Amaryl |
| glimepiride and pioglitazone | Duetact |
| glipizide | Glucotrol |
| glipizide and metformin | Metaglip |
| glyburide | DiaBeta, Glynase, Micronase |
| glyburide and metformin | Glucovance |
Most sulfonylurea medicines for type 2 diabetes can be taken once a day. Some need to be taken twice a day.
These medicines work for a long time and can cause low blood sugar. It is very important not to skip or delay meals when taking these medicines.
Glucovance is a combination medicine that contains glyburide and metformin, a biguanide.
Metaglip is a combination medicine that contains glipizide and metformin.
How It Works
Sulfonylurea medicines increase the amount of insulin produced by the pancreas. This is the primary action of these medicines.
Because Glucovance and Metaglip are combination medicines that contain metformin, they decrease the amount of sugar your liver makes and may increase your body's ability to respond to insulin.
Why It Is Used
Sulfonylurea medicines are prescribed when changes in diet, weight loss, and exercise do not keep the blood sugar level within a target range. When taking one of these medicines, it is still important to eat a balanced diet, exercise, and lose weight if needed.
These medicines can help control blood sugar levels in children and young adults who have type 2 diabetes and are overweight.
Sulfonylurea medicines are not safe if you:
- Are pregnant or trying to become pregnant. They may harm the fetus.
- Have liver or kidney problems. Sulfonylurea medicines are broken down by the liver and pass out of the body through urine produced in the kidneys.
Tell your doctor if you have had a serious allergic reaction to a sulfa antibiotic, such as Bactrim or Septra. You may not be able to use a sulfonylurea.
How Well It Works
Sulfonylurea medicines work rapidly to control elevated blood sugar levels. They often are the first medicine selected to treat people newly diagnosed with type 2 diabetes. Metformin is preferred for initial treatment, because it doesn't cause low blood sugar or weight gain. Most people have better control of their blood sugar by using a sulfonylurea medicine along with diet and exercise than by using diet and exercise alone.
But the medicine may become less effective after several years of use. Some people who no longer respond to one sulfonylurea may respond to a different one.
Sulfonylurea medicines decreased the risk for complications of the eyes (retinopathy), kidneys (nephropathy), and nerves (neuropathy).1 These medicines do not decrease fat (triglycerides) in the blood as does metformin.
Side Effects
Side effects are uncommon when sulfonylureas are taken as prescribed. Low blood sugar is the most common side effect. The risk of very low blood sugar is greater with medicines that work longer in the body.
Drinking alcohol increases the risk of a low blood sugar level if you take a sulfonylurea medicine. If you drink alcohol, limit yourself to only 1 to 2 drinks a day and eat something before you drink alcohol.
Sulfonylurea medicines can cause weight gain. They also tend to keep insulin levels in the body high for long periods of time. Over time, high levels of insulin (hyperinsulinemia) may increase your chances of getting heart disease.
Blood levels of vitamin B12 can decrease in some people who take metformin.
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
What To Think About
Sulfonylurea medicines are an effective treatment for many people who have type 2 diabetes. If one of these medicines keeps your blood sugar within a target range, your risks of long-term complications of diabetes can be reduced. Other important factors that contribute to complications include high blood pressure, being overweight, high cholesterol levels, and smoking.
Children
Few studies have been done on the use of oral medicines for type 2 diabetes in children. And they have not been approved by the U.S. Food and Drug Administration (FDA) for use in children. But because these oral medicines are safe for adults, most doctors use them to treat children who have type 2 diabetes.
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WebMD Medical Reference from Healthwise
Last Updated:
June 09, 2010
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Is This Normal?
Get the Facts Fast!Answer:
Your level is currently NormalHigh (hyperglycemia).Low (hypoglycemia). |
If the level is below 70 and you are experiencing symptoms such as shaking, sweating or difficulty thinking, you will need to raise the number immediately. A quick solution is to eat a few pieces of hard candy or 1 tablespoon of sugar or honey. Recheck your numbers again in 15 minutes to see if the number has gone up. If not, repeat the steps above or call your doctor.
People who experience hypoglycemia several times in a week should call their health care provider. It's important to monitor your levels each day so you can make sure your numbers are within the range. If you are pregnant always consult with your health care provider.
If the level is below 70 and you are experiencing symptoms such as shaking, sweating or difficulty thinking, you will need to raise the number immediately. A quick solution is to eat a few pieces of hard candy or 1 tablespoon of sugar or honey. Recheck your numbers again in 15 minutes to see if the number has gone up. If not, repeat the steps above or call your doctor.
People who experience hypoglycemia several times in a week should call their health care provider. It's important to monitor your levels each day so you can make sure your numbers are within the range. If you are pregnant always consult with your health care provider.
Your blood sugar level is slightly high. You should call your health care provider and ask if laboratory tests to check for diabetes are needed. If you are pregnant always consult with your health care provider.
Congratulations on taking steps to manage your health.
However, it's important to continue to track your numbers so that you can make lifestyle changes if needed. If you are pregnant always consult with your physician.
Your level is currently normal. However, if you are concerned about diabetes speak with your physician. There may be other risk factors that increase your risk for diabetes.
Your level is high if this reading was taken before eating. Aim for 70-130 before meals and less than 180 two hours after meals.
Even if your number is high, it's not too late for you to take control of your health and lower your blood sugar.
One of the first steps is to monitor your levels each day. If you are pregnant always consult with your physician.
Your blood sugar level may be high, depending on when you last ate. If you have not eaten for at least 8 hours, your blood sugar should be less than 100. If you've eaten within the last 2 hours, your blood sugar should be less than 140. You should call your health care provider and ask if you need laboratory tests to check for diabetes. If you are pregnant always consult with your health care provider.
Blood sugars consistently above 180 warrant prompt medical attention.
Even if your number is high, it's not too late for you to take control of your health and lower your blood sugar.
One of the first steps is to monitor your levels each day. If you are pregnant always consult with your physician.
Your blood sugar level is high. You should call your health care provider and ask if laboratory tests to check for diabetes are needed. If you are pregnant always consult with your health care provider.
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