Diabetes Health Center
Diabetic Nephropathy - Symptoms
There are no symptoms in the early stages of diabetic nephropathy. The only sign of kidney damage may be small amounts of protein leaking into the urine (microalbuminuria). Normally, protein is not found in urine except during periods of high fever, strenuous exercise, pregnancy, or infection.
In people with type 1 diabetes, diabetic nephropathy usually develops 5 to 10 years after the onset of diabetes. People with type 2 diabetes may find out that they already have a small amount of protein in the urine (microalbuminuria) at the time diabetes is diagnosed, because they may have had diabetes for several years.
As diabetic nephropathy progresses, your kidneys cannot do their job as well. Your kidneys cannot clear toxins or drugs from your body as well. And your kidneys cannot balance the chemicals in your blood very well. You may:
- Lose more protein in your urine (macroalbuminuria, also known as overt nephropathy).
- Have higher blood pressure.
- Have higher cholesterol and triglyceride levels.
You may have symptoms if your nephropathy gets worse. These symptoms include:
- Swelling ( edema), first in the feet and legs and later throughout your body.
- Poor appetite.
- Weight loss.
- Weakness.
- Feeling tired or worn out.
- Nausea or vomiting.
- Trouble sleeping.
See the topic Chronic Kidney Disease for more information.
If the kidneys are severely damaged, blood sugar levels may drop because the kidneys cannot remove excess insulin or filter oral medicines that increase insulin production, such as glipizide ( Glucotrol) or glyburide (for example, Micronase).
WebMD Medical Reference from Healthwise
Diabetic Nephropathy Topics
Indication
Uroxatral® (alfuzosin HCl 10 mg extended-release tablets) is an alpha1-blocker for the treatment of the signs and symptoms of BPH.
Important Safety Information
Do not take UROXATRAL if you have liver problems or if you are taking antifungal drugs like ketoconazole or itraconazole, or HIV drugs like ritonavir.
UROXATRAL can cause a sudden drop in blood pressure, especially when starting treatment. This may lead to fainting, dizziness, and lightheadedness. Do not drive, operate machinery, or do any dangerous activity until you know how UROXATRAL will affect you. This is especially important if you already have a problem with low blood pressure or take medicines to treat high blood pressure. There may be an increased risk of low blood pressure and fainting when taking UROXATRAL in combination with blood pressure medication or nitrates, or erectile dysfunction medication.
If considering cataract surgery (clouding of the eyes), tell your eye surgeon that you are currently taking UROXATRAL or have previously been treated with an alpha-blocker.
Before taking UROXATRAL, tell your doctor if you have kidney problems.
Also, tell your doctor if you or any family member(s) have or take medications for a rare heart condition known as congenital prolongation of the QT interval.
BPH and prostate cancer can cause the same symptoms. However, UROXATRAL is not a treatment for prostate cancer.
The most common side effects with UROXATRAL are dizziness, upper respiratory tract infection, headache, and tiredness.
Please see UROXATRAL full prescribing information.
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