Most people with prediabetes get better results by making lifestyle changes, such as losing weight, eating a healthy diet, and getting regular exercise, than with diabetes medicine.⁷

However, a health professional may prescribe a biguanide, usually metformin (Glucophage), because it can reduce insulin resistance-especially in patients with polycystic ovary syndrome. In some cases a health professional may prescribe thiazolidinediones (Actos or Avandia) to lower insulin resistance. Metformin is used much more frequently.

Ask your health professional whether diet and exercise are sufficient treatment or whether you should take medicine to lower your insulin resistance.