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Arthritis Drug for Diabetes

Reviewed By: Louise Chang,

SOURCES: 2008 Medical Reference from Medstar. Allison Goldfine, MD, Clinical Research Director, Joslin Diabetes Center; Steve Shoelson, MD, PhD, Harvard Medical School, Boston, MA.

© 1999-2011 Medstar Television

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Narrator:

When diet and weight loss weren't enough to control Mary Provost's type two diabetes, the 64-year-old was reluctant to go on a diabetes drug.

Mary Provost, Patient:

At the same time, I was having arthritis symptoms that were driving me just crazy.

Narrator:

Then she heard about a study At Joslin Diabetes Center to see if an old arthritis drug could treat type two diabetes.

Mary Provost, Patient:

I wasn't taking a drug for either of them but I thought two for one, a two-fer.

Narrator:

Joslin researchers had found that inflammation plays a big role in obesity-related diseases like diabetes. The study drug called salsalate (SAL-suh-LATE) is a safe inexpensive anti-inflammatory that's been used for arthritis for decades.

Steve Shoelson, MD, PhD, Diabetes Researcher, Joslin Diabetes Center:

And we hope that by targeting the inflammation that is caused by obesity, that we're actually getting at a root cause of the Type 2 diabetes.

Narrator:

Mary's blood sugar dropped steadily and her arthritis pain disappeared.

Allison Goldfine, MD, Clinical Research Director, Joslin Diabetes Center:

What we found was that in patients with diabetes, or with excess weight and risk for diabetes, consistently that the drugs appeared to lower blood sugars, and to improve the circulating inflammatory markers that seemed to be associated with diabetes and even cardiovascular risk.

Narrator:

Mary still takes salsalate for arthritis. She's able to garden, golf - even keep up with a puppy.

Mary Provost, Patient:

I'm brushing her and playing with her and taking her for walks. There's no way, no way I could have done that before.

Narrator:

She found a "two-fer" that has her feeling great. For WebMD, I'm Sandee LaMotte.

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