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Defend Diabetes Trial

Reviewed By: Louise Chang,

SOURCES: This Video is from the WebMD Video Archive. Thomas Donner, MD, Lead Investigator, Joslin Diabetes Center, University of Maryland, Baltimore.

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Narrator:

Justin Taylor is one of over two million Americans with type one diabetes. Over time, his body stopped making insulin completely. Now a pump delivers it for him.

Justin Taylor:

I was diagnosed right before I turned 17, about two months before. And my symptoms were mostly just urinating a lot and always being thirsty.

Narrator:

Early on, his blood sugars were easier to control because his body was still making some insulin.

Thomas Donner, M.D.:

When patients are first diagnosed, they usually have about 20% of their islet cells still functioning.

Narrator:

It's called the honeymoon phase. And now doctors want to see if they can keep it going.

Thomas Donner, M.D.:

By doing so, then it takes less demand on the patient to fully replace insulin which is very challenging.

Narrator:

So, in a study, newly diagnosed patients will receive an experimental drug called Otelixizumab (Oh-tah-lix-IZ-ew-mab).

Thomas Donner, M.D.:

This is an 8-day infusion. So they're infused for half an hour for 8 consecutive days and then they're done.

Narrator:

The drug, a type of antibody, could pull double duty. First, by stopping the immune system from attacking insulin-making cells. Second, by activating other t-cells to protect them. So far, the results are promising.

Thomas Donner, M.D.:

We have four-year data out now showing that patients who received the drug instead of placebo, have much lower insulin requirements.

Narrator:

Though it's too late for Justin, he understands the impact that would have on diabetes.

Justin Taylor:

If a drug like that came out, it would make it easier to control.

Narrator:

And there could be fewer complications down the road. For WebMD, I'm Damon Meharg.

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